镉砷接触工人肾功能损伤研究

Renal dysfunction in workers exposed to arsenic and cadmium

目的 探讨镉、砷对作业工人肾功能的联合作用。方法 以我国中南某厂镉、砷作业工人 114名为本研究的职业接触对象。以尿镉 (UCd)、尿砷 (UAs)作为接触标志物 ,尿 β2 微球蛋白(Uβ2 MG)、尿白蛋白 (UALB)、尿N 乙酰 β D 氨基葡萄糖苷酶 (UNAG)作为镉、砷致肾小管和肾小球损害的效应标志物。结果 UCd、UAs水平与Uβ2 MG、UALB、UNAG水平间均为正相关 ,具有明显的剂量-效应关系 (P <0 .0 5 ,P <0 .0 1)。结论 镉、砷对作业工人肾脏功能的联合作用主要表现为相加作用。

Objective To examine the nephrotoxicity induced caused by combined effect of arsenic and cadmium in exposed workers. Methods Urinary cadmium and arsenic were used as the exposure biomarkers of cadmium and arsenic.Urinary β_2-microglobulin(Uβ_2-MG),albumin(UALB) and N-acety-β-D-glucosaminidase(UNAG) were measured as the effective biomarkers of tubular and glomerular dysfunction induced by cadmium and arsenic.Results The combination of cadmium and arsenic induced more severe renal injury than that caused by either of the chemicals given alone.There were positive correlations and significant dose-effect among the concentrations of urinary cadmium,arsenic and levels of Uβ_2-MG,UALB,UNAG( P <0.05, P <0.01). Conclusion Cadmium combined with arsenic may have additive effect on renal dysfunction in workers exposed to arsenic and cadmium.