摘要
随着结核分枝杆菌全基因组序列测定的完成和后基因组学研究的发展,发现esat-6家族是一个免疫优势家族。该家族蛋白具有较强的免疫原性,且有的蛋白可能与结核分枝杆菌的毒力有关。本文综述了该家族蛋白的组成、免疫学特征、与结核分枝杆菌致病性的关系及其在结核病诊断试剂、新型疫苗方面的应用前景。
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