799株病原菌对常用抗生素的耐药性分析

Antibiotic-resistance of 799 Strains of Pathogenic Bacteria:An Analysis

目的 为临床合理、有效地使用抗生素提供依据。方法 采用回顾性调查 ,对 2 0 0 2年度我院检出的 799株病原菌的药敏试验结果进行统计学分析。结果 799株病原菌对临床常用抗生素均有不同程度的耐药 ,并有上升趋势 ,革兰阴性杆菌中以铜绿假单胞菌的耐药率和多重耐药率最高 ;革兰阳性球菌中以肠球菌耐药率最高 ,并出现耐受万古霉素菌株。结论 临床病原菌耐药问题不容忽视 ,应加大临床抗生素使用的监督力度 ,严格执行抗生素合理应用指导原则 ,减少用药的盲目性。

OBJECTIVE To provide scientific data for using antibiotic in clinic rationally and effectively. METHODS Retrospective investigation was performed for statistic analysis on antibiotic-resistance of 799 strains of pathogenic bacteria isolated from our hospital in 2002. RESULTS Their drug resistance was in different degrees and tended to increase. The rate of drug resistance and multiple drug resistance of Pseudomonas aeruginosa was the highest among Gram-negative germs; the rate of drug resistance of Enterococcus was the highest among Gram-positive ones and vancomycin resistant enterococci had been examined. CONCLUSIONS The drug resistance of pathogenic bacteria in clinic must not be neglected. It should reinforce supervision of using antibiotic in clinic and strictly perform The Guideline on Rationally Use of Antibiotics.