泌尿生殖道支原体体外药敏试验结果分析

Drug Sensitivity of Urogenital Mycoplasma in vitro

目的 探讨泌尿生殖道支原体感染状况及耐药谱。方法 应用支原体药敏试剂盒 ,对 5 98例泌尿生殖道标本进行支原体型别鉴定及 10种抗生素耐药性检测。结果 5 98例标本中检出支原体 2 33例 (39 0 % ) ,男女性别感染率分别为 39 1%和 38 8% ;解脲脲支原体 (Uu)阳性 15 9例 (6 8 2 % ) ,显著高于人型支原体 (Mh)感染(14例 ,6 0 % )及Uu Mh混合感染 (6 0例 ,2 5 8% ) (P <0 0 1) ;药敏试验显示 95 7%支原体患者有不同程度耐药 ;支原体型别不同、患者性别不同对 10种抗生素的耐药谱均不相同。结论 加强支原体的药敏检测 ,根据药敏结果合理用药 ,对防止支原体耐药株的产生具有重要意义。

OBJECTIVE To investigate urogenital mycoplasma infection and drug sensitivity. METHODS Drug sensitivity of 598 urogenital samples to ten antibiotics were detected with Mycoplasma Reagent Box. RESULTS From 598 cases 233 cases(39.0%,male 39.1% and female 38.8%)were with positive rate of culture. From them 159(68.2%) cases were with Ureaplasma urealyticum(Uu), more higher than Mycoplasma hominis(Mh)infection(14 cases, 6.0%)or complicated Uu and Mh infection(60 cases, 25.8%)(P<0.01).The result of drug sensitivity test showed that 95.7% mycoplasma were drug resistant. Uu, Mh and Uu-Mh isolated from both sexes had different drug resistance. CONCLUSIONS It is important to enhance the detection of drug resistance of mycoplasma, guide the drug use and prevent from producing antibiotic-resistant mycoplasma.