丹皮酚对白细胞聚集、花生四烯酸代谢及溶菌酶释放反应的影响

The Effect of paeonol on Human PMM Aggregation,Arachidonate Metabolism and Lysozyme Release

花生四烯酸(AA)、白三烯B_4(LTB_4)及广西眼镜蛇毒第Ⅳ组分(Cobra venom)在体外均可引起明显的白细胞聚集。丹皮酚(25～150μg/ml,终浓度)对AA、LTB_4、Cobra venom 诱导的白细胞聚集无抑制作用。在200μg/ml 时反而可增强AA、LTB_4、cobra venom 对白细胞的诱聚作用。丹皮酚对白细胞前列腺素E_2、血栓烷B_2的生成及白细胞溶菌酶的释放均无抑制作用。

AA,LTB_4 and cobra venom can induce PMM aggregation.Paenol(25-150μg/ml,final con-centration)didn't inhibit PMM aggregation induced by AA,LTB_4 and Cobra venom.At the concen-tration of 200μg/ml Paeonol can enhance PMM aggregation induced by AA,LRB_4 and cobra ven-om.Paeonol(50-200μg/ml,final concentration)had no effect on the production of PGE2 andTXB_2 and the release of Lysozyme of PMN.