全反式维甲酸对急性早幼粒细胞白血病的疗效

The Therapeutic Effects of All—trans Retinoic Acid on Acute Promyelocytic Leukemia

报告用国产全反式维甲酸治疗急性早幼粒细胞白血病34例,结果完全缓解(CR)率为97.1%。在治疗中,全组病人白细胞数都有增高现象,但未发生弥漫性血管内凝血。主要副作用为皮肤及口唇干燥、头痛等。

Thirty four patients with acute promyelocytic leukemia(APL)were treated with all—transretinoic acid.The complete remission rate was as high as 97.1%(33/34).All patients developed ahigh white blood cell count without developing DIC during the treatment.The major side effects inc-luded mild dryness of the skin and lilps,occasional headaches and so on.We conclude that the all—tr-ans retinoic acid is an excellent drug for differentiation induction therapy in APL.