摘要
疟原虫抗药性及疟蚊对杀虫剂抗性的产生和迅速扩散迫切需要研究新的疟疾防治方法 ,以控制该传染病的流行。根据自愿者试验、动物模型及现场研究结果 ,研制疫苗预防疟疾是可行的。当前 ,全球科学家正在研制 3种类型的疟疾疫苗——抗红内期原虫疫苗、抗红前期原虫疫苗和传播阻断疫苗 ,其中一些候选疫苗已进入临床试验 ,并产生有意义的结果。由于疟原虫具有复杂的生活史、抗原变异和多种入侵途径 ,有效疫苗的研制将面临极大的困难 。
The emergency and rapid spread of drug resistant parasites and mosquitoes resistant to insecticides urgently demand new tools to control the disease. It is feasible to develop malaria vaccine based on animal and volunteers test. Scientists around the world are working on 3 types of malaria vaccine——pre erythrocytic, blood stage and transmission blocking. Some of the vaccine candidates are being tested in clinical trials and have been shown to be promising. It is very difficult to find a successful malaria vaccine due to its complex life cycle, antigen variations and multiple invasion pathways, but the vaccine will finally be developed.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
2004年第1期1-4,共4页
Academic Journal of Second Military Medical University
基金
世界卫生组织专项基金 ( IDA 2 0 198)
国家杰出青年科学基金 ( 3 0 2 2 5 0 41)
关键词
疟疾
疫苗
预防
红内期
红前期
疟原虫
malaria
vaccine
pre erythrocytic
blood stage
transmission blocking
