单光子发射型计算机断层摄影术体积积分法估测甲状腺重量

Evaluation of volume of thyroid grand by single photon emission computed tomography volume-integration

目的 利用单光子发射型计算机断层摄影术 (SPECT)体积积分法估测甲状腺重量 ,为甲状腺功能亢进症 (简称甲亢 )患者的放射治疗提供精确的甲状腺重量。方法 对 39个甲状腺实验模型及 74例甲亢患者分别采用SPECT体积积分法及平面成像法估测甲状腺重量。在甲状腺实验模型组 ,将 2种方法估测的甲状腺重量分别与实验模型实际重量比较 ;在甲亢患者组 ,将 2种方法估测的甲状腺重量进行比较。结果 在甲状腺实验模型组 ,SPECT体积积分法估测的甲状腺重量与实验模型实际重量差异无统计学意义 (P均 >0 .0 5 ) ;而平面成像法估测的甲状腺重量与实验模型实际重量之间差异有统计学意义 (P 均 <0 .0 0 1)。在甲亢患者组 ,SPECT体积积分法估测的甲状腺重量(38.78± 8.6 5 ) g小于平面成像法估测的甲状腺重量 [(4 4 .90± 10 .5 7) g ,P <0 .0 0 1]。结论 SPECT体积积分法可准确估测甲状腺重量 ,这一方法能提高甲亢治愈率 。

Objective To evaluate the volume (mass) of thyroid grand by single photon emission computed tomography(SPECT) volume-integration,and to provide exact volume (mass) of thyroid grand for radioidine therapy in patients with hyperthyroidism. Methods Thyroid volume(mass) was evaluated by SPECT volume-integration and by plane image method in 39 experimental thyroid models and in 74 patients with hyperthyroidism,respectively. Volume (mass) of thyroid grand evaluated by both methods was compared with actual models volume in experimental thyroid models.Thyroid volume evaluated by SPECT volume-integration was compared with that evaluated by plane image method in patients with hyperthyroidism. Results The difference between actual volume of experimental thyroid models and that evaluated by SPECT volume-integration is not significant(P> 0.05),but the difference brtween actual volume of experimental thyroid models and that evaluated by plane image method is significant(P< 0.001).Average volume evaluated by SPECT volume-integration ( 38.78± 8.65) g is less than that evaluated by plane image method [( 44.90± 10.57) g,P< 0.001] in patients with hyperthyoidism.Conclusion The volume of thyroid grand may precisely be evaluated by SPECT volume-integration.This method may increase curative rate of hyperthyroidism,and decrease early of hypothyroidism after radioidine therapy in patients with hyperthyroidism.