摘要
目的:通过同供体肾移植及骨髓细胞输注,观察受者体内微嵌合体形成情况,探索同供体肾移植及骨髓细胞输注的安全性及近期效果。方法:4例肾移植受者于肾移植术后第1天、第3天输注同供体骨髓细胞,并与接受同一供体肾移植患者进行移植后的临床效果观察及免疫状态的分析比较。结果:接受同供体骨髓输注的4例肾移植受者临床效果良好,均产生免疫低反应。结论:同供体肾移植及骨髓细胞输注是一种可行的诱导免疫耐受的方法,且简便安全。
Objective:To study the security and effect of simultaneous the kid ney transplantation and donor bone marrow transfusion, and investigate microchim erism in the recipients. Methods:The donor bone marrow was transfused into 4 re nal allograft recipients. Allograft renal function,T lymphocyte subgroup and so me cytokines were analysed and compared to the control group. Results:Renal all ograft function was normal. There was immuno-hyporeactivity in 4 renal allograf t patients. Conclusion:Donor bone marrow transfusion was safe and beneficial. I t could induce specific immunologic tolerance in the renal allograft recipients.
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
北大核心
2004年第1期22-24,共3页
Journal of Nanjing Medical University(Natural Sciences)
基金
江苏省自然科学基金资助项目(BK97172)
关键词
肾移植
骨髓细胞输注
免疫耐受
微嵌合
immunologic tolerance
kidney transplantation
bone marrow trans fusion
microchimerism
