口服吗啡缓释片与静脉自控镇痛对晚期癌性疼痛的临床疗效比较

A comparative study of po controlled-release morphine tablets and patient-controlled intravenous analgesia in late stage cancer pain

目的 :综合比较吗啡缓释片和病人自控静脉镇痛在晚期癌症病人疼痛治疗中的临床效果。方法 :80例晚期癌症病人 ,随机分为 2组 ,每组 40例。吗啡缓释片组 (M组 )口服吗啡缓释片 90～ 2 70mg/d ,分 2次给药 ;病人自控静脉镇痛组 (PCIA组 )的给药方式为“负荷量 +背景量 +病人自控给药量”模式 ,药液配方为枸橼酸芬太尼 3mg ,氟哌利多5mg ,添加生理盐水至 10 0ml。比较两组镇痛效果、治疗费用、病人满意率、不良反应发生率。 结果 :两组日均用药量基本等效。PCIA组镇痛效果较好 ,镇静程度较低 ,不良反应发生率低 ,病人满意率高。结论 :PCIA在晚期癌症镇痛治疗中优点明显 ,安全性较高。

Aim:To compare the clinical analgesic efficacy of controlled-release morphine tablets and patient-controlled intravenous analgesia in late stage cancer patients.Methods:Eighty patients were randomly divided into 2 groups with 40 patients in each group.The patients of morphine group were given controlled-release morphine tablets with total dosage of 90～270mg/d,po,twice daily.The patients of PCIA group followed “loading dose+background dose+patients-controlled dose”mode.Fentanyl citrate 3 mg and droperidol 5 mg was resolved in 100 ml normal saline.The analgesic efficacy,cost,and patients’ satisfaction were compared.Results:The average dosages of analgesics in the two groups were almost the same.The patients of PCIA group got better analgesic effects,lower sedative degree,less adverse reaction,and had greater satisfaction.Conclusion:PCIA has apparent advantages in treatment of cancer pain with higher safety.