乳腺癌多药耐药性研究进展

Research Progress of Multidrug Resistance of Breast Cancer

目的 综述乳腺癌多药耐药性研究的最新进展。方法 采用文献回顾的方法 ,对目前国内、外有关乳腺癌多药耐药性的研究状况加以分析与综述。结果 乳腺癌多药耐药是多基因、多阶段、多步骤、多因素共同作用的结果。如何早期明确化疗药物的敏感性并选择适宜的个体化治疗方案 ,是避免化疗失败 ,提高患者生存率和生活质量的一个重要环节。结论 深入研究乳腺癌多药耐药的发生、发展机理 ,有助于临床预测化疗疗效 ,分析患者预后 ,并为最终解决多药耐药这一难题提供有益的帮助。

Objective To review the recent studies on the multidrug resistance of breast cancer. Methods The literatures of recent years on the studies of multidrug resistance, multidrug resistance protein and breast cancer resistance protein were reviewed. Results Multidrug resistance resulted from multiple factors. How to identify the sensibility of chemotherapy drugs and select individual therapeutic regime early were important to improve the survival rate and life quality of breast cancer patients.Conclusion These studies on multidrug resistance of breast cancer are helpful to predicting the effect and outcome of chemotherapy and overcoming the barrier of drug resistance.