MCP-1在大鼠视网膜缺血再灌注损伤中的表达及意义研究(英文)

Research of MCP-1 expression in rat's retina injured by ischemia-reperfusion

目的 了解MCP - 1在大鼠视网膜缺血再灌注损伤中的表达及意义。方法 建立大鼠视网膜缺血再灌注模型 ,以SABC法检测MCP - 1在视网膜中的表达 ,统计学分析。结果 MCP - 1在视网膜缺血再灌注 6h开始表达 ,第 2 4小时达到最高峰 ,4 8h开始表达减弱。结论 MCP - 1在视网膜缺血再灌注损伤中起重要作用。

Objective:The retina ischemia-reperfusion injury is caused by many factors. A lot of cell factors take part in it. Many researches suggest MCP-1 has special effect on leukocyte and lymphocyte.The research try to study the effect of MCP-1 in rat's retina ischemia-reperfusion injury.Methods:To employ the rat's retina ischemia-reperfusion model and use SABC method to test the expression of MCP-1 on retina.Results:There was no MCP-1 expressed in retina after ischemia-reperfusion injury for one hour. MCP-1 began to express in retina after ischemia-reperfusion injury for six hours, and expressed at most after ischemia-reperfusion injury for 24 hours. Then it began to decrease in 48 hours after ischemia-reperfusion injury, but it still expressed in retina in seventy-two hours after ischemia-reperfusion injury.Conclusions:MCP-1 plays an important role in rat's retina ischemia-reperfusion injury.