摘要
A new dynamic model for non-Fickian diffu-sion of calcium spark in cardiac myocytes was developed by introducing time lags on the basis of the microscale mass transport theory. Numerical simulation showed that the size of the calcium spark produced by the new dynamic model was larger than that of Fick diffusion and was in more agreement with experimental results. In addition, the time lags of the calcium spark in cardiac myocytes were about 0.1—0.8 ms. These results can be used to understand the mechanism of calcium spark diffusion in cardiac myocytes.
A new dynamic model for non-Fickian diffu-sion of calcium spark in cardiac myocytes was developed by introducing time lags on the basis of the microscale mass transport theory. Numerical simulation showed that the size of the calcium spark produced by the new dynamic model was larger than that of Fick diffusion and was in more agreement with experimental results. In addition, the time lags of the calcium spark in cardiac myocytes were about 0.1—0.8 ms. These results can be used to understand the mechanism of calcium spark diffusion in cardiac myocytes.
基金
supported by the National Natural Science Foundation of China(Grant No.10372007)
Bio-x center of Peking University and Japan Society for the Promotion of Science(PO2325).
关键词
动力学模型
钙离子
心脏肌细胞
非菲克扩散
数值仿真
生理学
calcium spark, non-Fickian diffusion, dynamic model, numerical simulation, cardiac myocytes.
