异长春花碱与顺铂联合治疗晚期非小细胞肺癌近期疗效观察

NVB and DDP combination chemotherapy in the treatment of advanced non-small cell lung cancer

目的 观察异长春花碱 (NVB)联合顺铂 (DDP)治疗晚期非小细胞肺癌 (NSCLC)的近期疗效与毒副反应。方法 共治疗 5 2例晚期NSCLC患者 :NVB 2 5mg/m2 静滴 ,第 1、8天 ,DDP 80mg/m2 ,第 1天 ,同时水化 3天。 2 1天为一周期 ,化疗 2周期后评价疗效 ,化疗期间记录毒副反应。结果 本组 5 2例患者完全缓解 (CR) 2例 ,部分缓解 (PR) 2 6例 ,稳定 (SD) 17例 ,进展 (PD) 7例 ,总有效率 (CR +PR)为 5 3 .8% ,NVB限制性毒性为白细胞下降、恶心呕吐及静脉炎。结论 以NVB和DDP联合化疗NSCLC有效率较高 ,毒副反应易耐受 。

Objective To evaluate the clinical effect and toxicity of NVB and DDP combination chemotherapy in the treatment of advanced non small cell lung cancer. Methods All 52 patients were treated with NP regimen: NVB 25 mg/m 2 iv, D1, D8; DDP 80 mg/m 2 iv, D1. The regimen was repeated every 3 weeks, tumor assessment was done after 2 cycles. Results There were 2 complete responses (CR) and 26 partial responses (PR). The overall responses rate (CR+PR) was 53.8%, and the main toxicity was leucopenia, nause, vomiting and phlebitis. Conclusion The NP regimen is effective in the treatment of advanced non small cell lung cancer, the toxicity is well tolerated. Hence the regimen can be regarded as first line regimen of advanced non small cell lung cancer.