261例恶性肿瘤患者血液流变学的检测结果

HEMORHEOLOCICAL DETERMINATION IN 261 PATIENTS WITH MALIGNANT TUMOURS

检测261例恶性肿瘤(肺癌、乳腺癌、胃癌、原发性肝癌、恶性淋巴瘤、食管癌及结直肠癌等)患者的血液流变学水平,并与健康人作了比较。检测结果表明,恶性肿瘤患者的血浆粘度,全血低切粘度及血沉均有明显升高(P<0.05和0.01);而血细胞压积(除乳腺癌外)均低于健康人(P<0.01)。纤维蛋白原水平除恶性淋巴瘤及肠癌外均有明显增高(P<0.05和0.01)。肿瘤复发转移患者仅血浆粘度高于无复发转移者(P<0.01)。作者还对原发性肝癌和肝硬化病人、胃癌和慢性胃炎病人的血液流变学各项指标做了比较分析,结果发现某些指标有明显差异,以血浆粘度变化尤为明显。因此认为血浆粘度对良、恶性的肝、胃疾患可能有一定的鉴别诊断意义。

In the present article. A comparative study was conducted on 261 patients with malignant turnouts and 93 healthy controls. The 261 patients were suffering from breast cancer, gastric carcinoma, primary carcinoma of liver, malignant lymphoma, esophageal carcinoma or other cancers. The results showed that all the patients with malignant tumours were associated with a significant rise in plasma viscosity, whole blood low sheathed viscosity and ESR (P<0.05 ～0.01). The hmenatacrit of these patients, except the patients with breast cancer, were lower than the healthy controls. The fibrinogen level of all the patients, except the patients with malignant lymphoma and colorectal carcinoma, had a significant rise. The plasma viscosity in patients who had had relapses and metastasis were obviouly higher than the patients who hadn't relapses and metsatasis. In this article, a comparative study of hmemorheological level of the patients with primary carcinoma of liver and cirrhosis, and gastric cancer and chronic gastritist were also carried out. The results indicated that there is marked diference in some indexes of hemorheological level, esecially plasma viscosity. Therefore, the plasma viscosity is of some value in identification of simple liver and stomach diseases from malignant liver and stomach diseases.