摘要
用随机抽样方法,对116例精神病患者进行观察,结果,服用酚噻嗪类药物90例180眼,角膜、晶状体发生改变58例116眼,占64.4％;服用氯氮平作对照组26例52眼,角膜、晶状体改变18例20眼,占38.4％,两组有非常显著性差异(P<0.01)。随着酚噻嗪类药物服用时间延长,其阳性率上升,提示:长期应用酚噻嗪类药物可致角膜、晶状体混浊,对视力有一定影响。
116 psychiatric patients were investigated at random. The results showed that the cloudy cornea and crystalline lens occured in 58 eases and 116 eyes (64.4％) of the 90 cases and 180 eyes treated with phenothiazines. However, in the control group of 26 patients and 52 eyes treated with clozapine, the cloudy cornea and crystalline lens occured only in 18 cases and 20 eyes (38. 4％). There were significant differences between the two groups (P<0. 01). Side effects oecured as phenothiazines contunued to be used. We suggest that long—term use of pheno thiaznes can lead to cloudy cornea and crystalline lens and damage the eye sights.
出处
《泰山医学院学报》
CAS
1992年第3期282-286,共5页
Journal of Taishan Medical College
关键词
酚噻嗪
氯氮平
角膜
晶状体
phenothiazines
clozapine
cornea
crystalline lens
