尿激酶受体在肺癌组织中的表达

The Expression of Urokinase-type Plasminogen Activator Receptor in Lu ng Cancer

研究尿激酶受体 (uPAR)在肺癌组织和非肺癌组织中表达的差异 ,探讨uPAR与肺癌浸润转移的关系。方法 用免疫组织化学S -P法检测uPAR在 52例肺部组织标本中的表达。结果 肺癌组uPAR的阳性表达率为 88.89% ,非肺癌组uPAR的阳性表达率为 6.2 5% ,两组比较差异有高度统计学意义 (P <0 .0 0 0 1)。uPAR的表达与肺癌患者的病理类型、性别和年龄无关 (P >0 .0 5)。结论 肺癌组织中有uPAR的异常高表达 ,uPAR在肺癌的生长。

Objective To study the difference of the expression of urokinase_type plsminogen activator receptor (uPAR) between human lung carcinom a tissues and non_malignant tissues.Abstract:Objective To study the difference of the expression of urokinase_type plsminogen activator receptor (uPAR) between human lung carcinom a tissues and non_malignant tissues.Methods The expression of (uPAR ) in 52 pulmonary tissues obtained through thoracic operation and bronchos copy were examined by S_P immunohistochemical technique.Results T he positive rate of uPAR in the lung cancer cases was 88.89% and that in the non _malignant cases was 6.25%.The difference of the two groups was statistically si gnificant(P<0.0001),but the expression of uPAR in the lung cancer did not show a significant correlation with age,sex and histological classification(P >0.05).Conclusion There is expression of uPAR in the tumor t issue,and uPAR plays a important role in promoting tumor growth,invasion and met astasis.