急性高原暴露左心房容积变化与高原病的关系

Relation of left atrial volume with acute mountain sickness upon the acute exposure to high altitude

目的:探讨急性高原暴露发生急性高原病时左心房的容积变化与急性高原病的关系。方法:选择初上高原发生急性高原病人员作为高原病组,同期选择性别、年龄匹配的未发生高原反应人员作为对照组,采用超声心动图检测两组每搏输出量(SV)、心输出量(CO)、左心房容积指数(LAVI)、二尖瓣下血流速度E以及A等指标。结果:上高原前两组SV、CO、LAVI、E、A以及E/A等无统计学差异(P均>0.05);与上高原前比较,高原病组上高原后SV、E峰、E/A减小,CO、A峰、LAVI增加(P<0.05),对照组上高原后E峰、E/A减小,CO、A峰增加(P均<0.05),LAVI以及SV无显著变化(P>0.05);与对照组比较,上高原后,高原病组LAVI增加(P<0.05),SV、A峰减小(P<0.05)。结论:急性高原暴露后发生急性高原病可能和左心房功能减低存在一定的关系。

Objective:To investigate the relation of left atrial volume with acute mountain sickness(AMS)upon the acute exposure to high altitude.Methods:Those patients with AMS who came to plateau for the first time were selected as AMS group while those with matching sex and age but without high altitude reaction during the same period were selected as control group.Stroke volume(SV),cardiac output(CO),left atrial volume index(LAVI),speed of blood flow under mitral valve(E and A)of all subjects were obtained.Results:There were no significant differences in SV,CO,LAVI,E,A and E/A between the two groups before exposure to plateau(P>0.05).Compared with before exposure to plateau,SV,E,E/A were decreased while CO,A,LAVI were increased in AMS group(P<0.05),but E,E/A were decreased while CO,A were increased(P<0.05)and LAVI,SV remained the same(P>0.05)in control group after exposure to plateau.Compared with control group,LAVI were increased while SV,A were decreased in AMS group(P<0.05)after exposure to plateau.Conclusion:Development of AMS may be related to reduced left atrial function upon the exposure to plateau.