应用计算机软件评测急进高原大脑记忆障碍的高原实地研究

Altitude field study on evaluation of memory impairment caused by rapid ascent to plateau using computer software

目的:探讨计算机软件评测急进高原大脑记忆障碍的可行性。方法:选取20例志愿者,采用乘车的方式,3h内快速将他们从平原运送到4 280m高原。在平原时、在初到高原时和在高原停留3h后这3个时间点采集志愿者的心率、血压和血氧饱和度;在初到高原时和在高原停留3h后这2个时间点填写急性高原反应自测表;在平原时和在高原停留3h后这2个时间点,应用计算机软件评测志愿者的瞬时记忆和短时记忆水平。结果:乘车3h快速抵达4 280m高原后,志愿者的心率和收缩压均较平原时升高(P<0.05),血氧饱和度较平原时降低(P<0.05);在此海拔停留3h后,4例(20%)出现急性高原反应;志愿者在高原停留3h后的听觉数字广度记忆、图片回忆和图片再认记忆的测试成绩较平原时降低(P<0.05)。结论:计算机软件记忆评测法简便易行、高效快速,在高原实地研究中作为记忆测试手段具有一定实用意义。

Objective:To explore the feasibilities of computerized evaluation of memory impairment caused by rapid ascent to high altitude.Methods:Twenty volunteers were rapidly transported by car from the plain to a plateau with an altitude of 4 280 m within 3h.Heart rate(HR),blood pressure(BP),and arterial oxygen saturation(SaO2)were measured at three time-points:on the plain,immediately after arrival on the plateau,and 3hafter arrival.Self-report measures of acute mountain sickness(AMS)were completed only after the immediate arrival and 3hafter arrival.Instantaneous and short-term memory were measured on the plain and 3hafter arrival on the plateau by using a computer software.Results:Compared to the plain measurements,HR and systolic BP significantly increased after arriving at the 4 280 m plateau(P <0.05),whereas SaO2 significantly decreased(P <0.05).Four participants(20%)developed acute mountain sickness(AMS)after 3hon the plateau.Memory performance of auditory digit-span test,picture recall test,and picture recognition test were significantly poorer on the plateau(P<0.05).Conclusion:Computerized evaluation of memory is simple,fast and efficient,which may have some practical significance using as a memory test tool on the plateau field study.