尼克地尔联合替格瑞洛治疗PCI术后难治性心绞痛疗效观察

Effect of nicorandil associated with ticagrelor on refractory angina pectoris after percutaneous coronary intervention

目的:观察尼克地尔联合替格瑞洛对PCI术后难治性心绞痛的治疗效果。方法:将60例PCI术后出现难治性心绞痛患者随机分为2组,对照组30例给予标准抗心绞痛治疗,治疗组30例在对照组治疗基础上给予尼克地尔联合替格瑞洛。2组治疗1周后观察心绞痛发作情况。结果:治疗组心绞痛缓解明显,总有效率达86.67%,与对照组比较差异有统计学意义(P<0.05)。结论:尼克地尔联合替格瑞洛治疗PCI术后难治性心绞痛效果较好,对心肌供血改善有一定疗效。

Objective:To observe the therapeutic effect of nicorandil associated with ticagrelor on refractory angina pectoris after percutaneous coronary intervention(PCI),Methods:Sixty patients with refractory angina pectoris after PCI were equally randomized into treatment group and control group.The patients in control group were given conventional antianginal therapy,while the patients in treatment group were given nicorandil associated with ticagrelor on the basis of routine treatment.After one week of medication,the times and duration of angina attacks were observed and compared.Results:The times and duration of angina attacks in treatment group were significantly lower than that of control group(P <0.05),and the total effective rate was 86.67%.Conclusion:On the basis of routine treatment,nicorandil associated with ticagrelor could attenuate refractory angina pectoris after PCI,which may be related with the improvement of blood supply in myocardium.