5-氨基酮戊酸光动力疗法(ALA-PDT)治疗尖锐湿疣影响因素及预后探讨

Efficacy of 5-aminolevulinic acid photodynamic treating genital warts:the impact factors and prognosis analysing

目的:研究5-氨基酮戊酸光动力疗法(ALA-PDT)在尖锐湿疣临床治疗中的效果,并探讨其影响因素和预后情况。方法:我院治疗的尖锐湿疣患者60例,随机分为两组。治疗组采用ALA-PDT治疗;对照组采用液氮冷冻治疗,比较两组治疗效果和预后情况。结果:对照组临床治愈率为66.67%,低于治疗组的93.33%(P<0.05);治疗组复发率低于对照组(P<0.05)。结论:应用ALA-PDT疗法治疗尖锐湿疣疗效显著,复发率较液氮冷冻治疗低。

Objective:To study the efficacy of 5-aminolevulinic acid photodynamic therapy(ALAPDT)in treating genital warts,and to analyse the relative factors and its prognosis.Methods:Sixty cases with genital warts in our hospital were included into this study.The cases were assigned into two groups in the randomized manner.The obeservation group was treated with ALA-PDT,and the control group treated with liquid nitrogen cryotherapy.The efficacy and prognosis were compared between the two groups.Results:The clinical curing rate control group was 66.67% and that of the obeservation group was93.33%.The significant difference was found(P<0.05).The recurrent rate of the obeservation group was significantly lower the that of the control(P<0.05).Conclusion:The application of ALA-PDT therapy is significant efficacious in treating genital warts with very lower recurrent rate compared with liquid nitrogen cryotherapy.