COPD急性加重期患者的hs-CRP、PCT和BNP水平的变化及临床诊断价值分析

Changes of hs-CRP,PCT and BNP levels in patients with acute exacerbation of COPD and the clinical diagnostic value

目的:探究并分析临床慢性阻塞性肺疾病(COPD)急性加重期患者的hs-CRP、PCT和BNP水平的变化和诊断价值。方法:选取我院2013-08~2015-09接诊的300例COPD急性加重期患者为试验组,另选同期180例健康体检者为对照组;试验组于刚入院和住院10d后,对照组于体检时,均清晨空腹抽取2ml肘正中静脉血,用于超敏C反应蛋白(hs-CRP)、降钙素原(PCT)和脑钠肽(BNP)的检测,并对检测结果进行对比分析。结果:治疗后,试验组hs-CRP、PCT和BNP水平明显低于治疗前,但明显高于健康对照组,具有显著性差异(P<0.05)。结论:对于临床COPD急性加重期患者,体内hs-CRP、PCT和BNP水平明显升高,有较好的临床诊断价值。

Objective:To explore and analyze the changes of hs-CRP,PCT and BNP levels in patients with acute exacerbation of chronic obstructive pulmonary disease(COPD)and the diagnostic value.Methods:A total of 300 patients with acute exacerbation of COPD admitted in our hospital from 2013-08 to 2015-09 were included as the treatment group,and 180 healthy cases for physical examination were selected as the control group.Serum high sensitive C reactive protein(hs-CRP),procalcitonin(PCT)and brain natriuretic peptide(BNP)of all subjects were tested at the time of admission and ten days after.Results:The hs-CRP,PCT and BNP in the treatment group was significantly lower after the treatment than before,and the difference was significant(P<0.05).After the treatment,hs-CRP,PCT and BNP were significantly higher in the treatment group than those in the control group,and the difference was significant(P<0.05).Conclusion:Serum hs-CRP,PCT and BNP would increase and have high clinical diagnostic value in the patients with acute exacerbation of COPD.