红景天苷抑制低氧诱导的血管渗出

Inhibition of hypoxia-induced vascular leakage by salidroside

目的:探讨红景天苷对低氧诱导的血管渗出和炎症的抑制作用及其机制。方法:将空白对照组、低氧组、低氧及红景天苷组大鼠暴露于海拔6000 m的缺氧环境12h,检测大鼠肺血管渗出量、氧化应激因子(NFkB)、炎症因子(IL-1、TNF-α)、细胞粘连分子(ICAM-I、E-选择素)的变化。结果:与空白对照组比较,低氧组大鼠肺血管渗出量,NFkB、IL-1、TNF-α、ICAM-I、E-选择素表达均显著增加(P<0.05);与低氧组比较,低氧及红景天苷组大鼠肺血管渗出量、NFkB、IL-1、TNF-α、ICAM-I、E-选择素表达均显著减少(P<0.05)。结论:红景天苷通过抑制肺血管渗出及氧化应激因子、炎症因子、细胞粘连分子的表达,减轻高原性肺水肿的发生,提高高原环境适应能力。

Objective:To discuss the effect of salidroside on hypoxia-induced vascular leakage and inflammation and its mechanism.Methods:The rats in control group,hypoxic group,and hypoxiasalidroside group were exposed to hypoxic environment(altitude of 6000 m)for 12 hours,and the pulmonary vascular leakage,oxidative stress factor(NFkB),inflammatory cytokines(IL-1,TNF-α),and cell adhesion molecules(ICAM-I,E-selectin)were determined.Results:The pulmonary vascular leakage and the expressions of NFkB,IL-1,TNF-α,ICAM-I and E-selectin in hypoxic group were significantly higher than those in control group(P<0.05),but were obviously lower than those in hypoxia-salidroside group(P <0.05).Conclusion:The salidroside inhibits pulmonary vascular leakage and the expressions of oxidative stress,inflammatory cytokines and cell adhesion molecules,which can improve the high altitude pulmonary edema and increase the adaptability in high altitude environment.