摘要
目的:探讨肿瘤坏死因子(tumor necrosis factor-α,TNF-α)和白介素6(interleukin-6,IL-6)在子痫前期的作用。方法:轻度、重度子痫前期患者和同期正常妊娠者各20例,用ELISA法检测血清中TNF-α、IL-6水平。结果:子痫前期患者血清中TNF-α、IL-6水平明显高于正常对照组(P<0.05);轻度和重度子痫前期患者间无差异(P>0.05)。结论:TNF-α、IL-6表达水平在子痫前期患者血清中显著升高,可能参与了子痫前期的发病过程。
Objective:To investigate the role of tumor necrosis factor alpha(TNF-α)and interleukin6(IL-6)in patients with preeclampsia.Methods:Sixty patients with mild preeclampsia,severe preeclampsia or normal pregnancy were randomly divided into 3groups,each group contained 20 cases.TNF-αand IL-6level in serum by ELISA were detected.Results:IL-6and TNF-αlevel in preeclampsia patients serum were significantly higher than those in normal control group(P<0.05).There was no difference between patients with mild and severe preeclampsia(P>0.05).Conclusion:The expression of TNF-αand IL-6is significantly increased in the serum of preeclampsia patients,which may be involved in the pathogenesis of preeclampsia.
出处
《西北国防医学杂志》
CAS
2016年第10期663-665,共3页
Medical Journal of National Defending Forces in Northwest China
