新疆哈萨克族、汉族原发性高血压患者血浆儿茶酚抑素水平的对比研究

A comparative study about the levels of plasma catestatin in Han and Kazakh populations with hypertension in Xinjiang

目的:分析新疆哈萨克族(哈族)、汉族原发性高血压(EH)患者和正常血压者血浆儿茶酚抑素(CST)水平的差异,探讨其与血压、血压变异性(BPV)、体质量指数(BMI)、稳态模型评价(HOMA)指数、血脂等的关系。方法:入选哈、汉族EH及血压正常者共180例,平均年龄35~75(47.34±9.35)岁,哈、汉族EH和血压正常者分别占46、44例和45、45例。观察记录血压水平、BPV、BMI、HOMA指数、血脂等指标,并检测其血浆CST水平,比较上述指标与CST的关系。结果:哈、汉族EH患者的CST水平有显著差异(P<0.05);而血压正常者CST无明显差异(P>0.05)。当血压、BMI、血脂和HOMA指数在分级相同情况下,EH的CST水平在两民族间仍然存在着显著差异(P<0.05)。EH中哈、汉族血压变异性与CST水平呈正相关。结论:新疆哈、汉族EH患者血浆CST水平与BMI、血脂、HOMA指数、BPV存在相关性。

Objective:To analyze the differences of plasma catechins inhibition(CST)levels between kazak(Ha)and Han nationality patients with primary hypertension(PH)in Xinjiang,and to explore the relations of CST with blood pressure(BP),blood pressure variability(BPV),body mass index(BMI),the steady-state model assessment(HOMA)index,blood lipids.Methods:Ninety-one patients with PH(46were Ha and 45 were Han nationalities)were selected,and 89 subjects with normal BP(44were Ha and 45 were Han nationalities)used as control.The mean age of all subjects was(47.34±9.35)years old(from 35 to 75years).BP,BPV,BMI,HOMA index,and blood lipids et al were observed while blood levels of CST were detected.The relations between the index above were analyzed.Results:There was significantly difference in the levels of CST between Ha and Han nationalities in patients with PH(P<0.05)but there was no difference in subjects with normal BP(P>0.05).There was significantly difference in the levels of CST between Ha and Han nationalities in PH patients with the same grade of BP,BMI,blood lipids and HOMA index(P<0.05).BPV of Ha and Han nationalities was positively correlated to the levels of CST in patients with PH(P <0.05).Conclusion:The blood levels of CST are correlated to BMI,blood lipids,HOMA index,and BPV in Ha,Han patients with PH.