摘要
目的:探讨神经管畸形(neural tube defects,NTDs)发生的相关因素,为及时预防和干预提供理论依据。方法:采用1∶1匹配的病例对照研究,对174例NTDs患儿的母亲和174例正常儿的母亲进行回顾性调查,运用SPSS 22.0软件进行单因素和多因素统计分析。结果:多因素Logistic回归结果示:母亲职业危险因素(OR=2.28)、既往缺陷儿史(OR=6.95)、母亲发热(OR=2.02)、被动吸烟(OR=2.59)和食用发芽土豆(OR=1.91)是NTDs的危险因素,而食用肉蛋奶(OR=0.71)和孕期叶酸应用(OR=0.60)是保护因素。结论:母亲职业危险因素、既往缺陷儿史、母亲发热、被动吸烟和食用发芽土豆是NTDs的危险因素,食用肉蛋奶和孕期叶酸应用是NTDs的保护因素。
Objective:To discuss the related factors of neural tube defects(NTDs),and to provide theoretical basis for timely prevention and intervention.Methods:A 1∶1 matched case-control study was conducted,and 174 mothers of children with NTDs and 174 mothers of normal children participate were investigated retrospectively.SPSS 22.0 software was used for univariate and multivariate statistical analysis.Results:The results of multivariate Logistic regression showed that mother occupational risk factors(OR=2.28),history of previously deficient children(OR=6.95),maternal fever(OR=2.02),passive smoking(OR=2.59),and consumption of germinated potatoes(OR=1.91)were risk factors of NTDs,meat,egg,milk(OR=0.71)and folic acid application during pregnancy(OR=0.60)were protective factors.Conclusion:Mother occupational risk factors,history of previous deficient children,maternal fever,passive smoking,and consumption of germinated potatoes are risk factors for NTDs.Meat,egg,milk and folic acid application during pregnancy are protective factors for NTDs.
作者
姜春倩
孙妮
李艳萍
宋迎冬
郭霜
徐丁
JIANG Chunqian;SUN Ni;LI Yanping;SONG Yingdong;GUO Shuang;XU Ding(Department of Pediatrics,the Second Hospital of Lanzhou University,Lanzhou 730030,China;Department of Urology,the Second Hospital of Lanzhou University)
出处
《西北国防医学杂志》
CAS
2019年第2期113-118,共6页
Medical Journal of National Defending Forces in Northwest China