南通市如皋县宫颈浸润性鳞癌的地区差异及其与HPV16、HPV18感染的关系

The Correlation between the Infection of HPV16,HPV18 and the Geograph ical Features of Invasive Cervical Cancer in Rugao County,Nantong City

目的 探讨人乳头状瘤病毒 16和 18型 (HPV16、HPV18)感染状况与宫颈癌的地区分布间的相关性。方法 应用免疫组化技术 ,对如皋县东北部 (宫颈癌高发区 )的宫颈浸润性鳞癌 3 9例和西南部 (低发区 )的宫颈浸润性鳞癌 3 8例分别进行HPV16和HPV18检测。结果 HPV16在高发区和低发区的阳性率分别为 64.1%和71.0 5% (P >0 .0 5) ,HPV18在高发区和低发区的阳性率分别为 3 8.46%和 42 .1% (P >0 .0 5)。另外本资料显示高发区患者年龄 (平均 54.2岁 )较低发区 (平均 61岁 )小 (P <0 .0 5)。结论 HPV16和HPV18作为宫颈鳞癌的病原学因子 ,其在不同地区间可能是相似的。本研究中高。

Objective To investigate the correlation between the p revalence of HPV16,HPV18 and the geographical features of invasive cervical squa mous carcinoma (CSC).Methods An immunohistochemical staining wa s used to detect the expression of HPV16 and HPV18 in 39 cases and 38 cases of C SC.Which come from the Northeast (the district with higher incidence of cervical cancer)and the Southwest (the incidence of cervical cancer is lower) of Rugao C ounty,respectively.Results Positive rates of HPV16 in the highe r incidence area group and the lower incidence area group were 64.1% ,71.05%, respectively.And positive rates of HPV18 in the same series were 38.46%,42.1%,re spectively,There was no significant difference statistically (P>0.05).Howev er,the ages of patients in the higher incidence area (average age 54.2) was sign ificantly younger than in the lower area (average age 61,0.05>P>0.01).Conclusions Positive rates of HPV16 and HPV18 immunohistochemical s taining in the group of the high incidence area of cervical cancer is similar to that in the lower incidence area.It was suggested that the etiological factors were probably also alike.