UV/H_2O_2降解水溶液中抗癫痫药物苯巴比妥

Photodegradation of antiepileptic drug phenobarbital in aqueous solution by UV / H_2O_2

采用UV/H2O2法对水溶液中的抗癫痫药物苯巴比妥(PBB)进行降解处理。研究发现:PBB的光解率随H2O2量的增加而增加,随PBB初始浓度的增加而降低。在UV/H2O2体系下PBB紫外光解的最佳p H为10.9。Cl-的存在会降低PBB的光解率,低浓度HCO-3的存在会增加PBB的光解率,高浓度的HCO-3的存在会抑制PBB的光解率。采用离子色谱和LC-MS-MS对PBB光解后的主要产物进行分析,提出了PBB可能的紫外光降解途径。结果表明:UV/H2O2法是去除水溶液中PBB的一种十分有效的方法。

The paper used UV/H2 O2 method to remove antiepileptic drug phenobarbital in aqueous solu-tion.The degradation rate of phenobarbital increases with the enhance of H 2 O2 dosage .The photodegra-dation speed of phenobarbital decreased with the increase of phenobarbital initial concentration .The opti-mal pH value for Phenobarbital photodegradation in UV/H2 O2 system is 10.9.The existence of Cl -can decrease degradation rate of Phenobarbital .The existence of low concentration of HCO 3-can increase phenobarbital degradation rate ,while the high concentration of HCO 3-can decrease phenobarbital degra-dation rate .The paper applied the ion chromatography and LC -MS-MS to analyze the main product af-ter degradation rate of Phenobarbital ,and propose the possible degradation way of ultraviolet of PBB .were detected and identified during phenobarbital photooxidation process .UV/H2 O2 has been proven to be an effective method for removal of phenobarbital from aqueous solution .