艾滋病合并肺孢子菌肺炎治疗研究进展

Progress in treatment of pneumocystis pneumonia in patients with AIDS

肺孢子菌肺炎(PCP)是艾滋病(AIDS)病人最常见机会性感染之一,常发生在CD4+T淋巴细胞计数<200个/μL的病人中,是艾滋病病人住院和死亡的主要原因之一。综合治疗是降低病死率的关键,主要包括:抗病原体治疗、辅助性治疗、呼吸支持治疗以及联合抗病毒治疗4个方面。近年来,相关研究在上述各治疗环节均取得了一定进展,文章就此方面进行综述。

Pneumocystis pneumonia(PCP)is one of common opportunistic infections in patients with AIDS(acquired immunodeficiency syndrome),often occurring in patients with CD4 cell counts below 200/μL,which is one of the main causes of hospitalization and death among AIDS patients.Comprehensive treatment is key to reduce mortality,mainly including four aspects:antipathogen treatment,adjunctive steroid therapy,respiratory support therapy and combined antiretroviral therapy.In recent years,researches have made progress in each of the above-mentioned treatment,and this article aims to summarize the progress.