肺癌与慢性阻塞性肺疾病相关性研究进展

A Review of the Research on the Correlations Between Lung Cancer and Chronic Obstructive Pulmonary Disease

许多流行病学研究一直将肺癌的发展与慢性阻塞性肺疾病(chronic obstructive pulmonary disease, COPD)的存在联系在一起,二者均有发病率高、死亡率高的特点。有研究显示,肺癌和COPD具有共同的致病因素,并将COPD列为肺癌的独立危险因素之一。该文对二者潜在的共同发病机制的研究进展进行了综述。

Many epidemiological studies have linked the development of lung cancer with the existence of chronic obstructive pulmonary disease(COPD),both of which are symbolized by high morbidity and mortality.Research shows that lung cancer and COPD have common pathogenic factors,and COPD is listed as one of independent risk factors causing lung cancer.There is an ever-growing bundle of evidence that suggests a close association between persistent chronic inflammation,COPD and lung cancer.A few potential targets of genetic susceptibility locus for COPD and lung cancer have been suggested.This article reviews the research on the potential common pathogenesis of lung cancer and COPD to explore whether COPD can be a pathogenic factor for lung cancer.