蛋白磷酸酶2A影响胰岛素调节的研究进展

Progress on the Effects of Protein Phosphatase 2A on Insulin Regulation

胰岛素分泌以及胰岛素信号通路中涉及大量的蛋白磷酸化与去磷酸化,蛋白磷酸酶2A(protein phosphatase 2A, PP2A)作为真核生物细胞内主要的丝氨酸/苏氨酸磷酸酶,在代谢疾病发生中的作用越来越受到关注。截至目前的研究表明, PP2A可以影响胰岛素的分泌以及周边组织对胰岛素的应答,胰岛素也能够影响PP2A的活性与蛋白水平, PP2A与胰岛素抵抗的关系近年来也成为研究的热点。该文对PP2A在机体胰岛素调节中的作用研究作一综述,希望有助于研究者们对此有更好的认识。

Numerous protein phosphorylation and dephosphorylation are involved in insulin secretion and insulin signaling pathway.Protein phosphatase 2A(PP2A) is one of the most abundant serine/threonine phosphatases in eukaryotic cells,and its role in metabolic disease is given more and more attention.So far,studies have shown that PP2A affects the secretion of insulin and the response of peripheral tissues to insulin,insulin also affects the activity and protein level of PP2A.The relationship between PP2A and insulin resistance has also become a hot topic in recent years.This article reviews the role of PP2A in insulin regulation,which might help to give researchers a further understanding of its important role in insulin regulation.