翻译后修饰及微管结合蛋白对微管动态结构与功能的调控

Regulation of Microtubule Dynamics and Functions by Post-Translational Modifications and Microtubule-Binding Proteins

微管是处于高度动态变化中的细胞结构。微管的动态性对于微管在细胞内许多特定功能的发挥至关重要。细胞内存在许多微管结合蛋白,对于微管的动态性及微管相关的细胞活动起着重要的调节作用,而微管结合蛋白与微管的相互作用又受到微管蛋白的翻译后修饰的调控。该综述主要讨论微管蛋白的翻译后修饰和微管结合蛋白如何影响微管动态结构,进而调控以微管为基础的细胞活动。

Microtubules are highly dynamic cellular structures,and the dynamic property of microtubules is essential for various cellular activities.Microtubule-binding proteins play important roles in regulating microtubule dynamics and microtubule-mediated cell activities.The interaction of microtubule-binding proteins with microtubules is regulated by post-translational modifications of tubulin.In this review,we discuss how tubulin post-translational modifications and microtubule-binding proteins affect microtubule dynamics and microtubule-mediated cellular activities.