SETDB1的生物学功能及其在疾病发生中的作用机理研究进展

Advances of Biological Function and Mechanisms of SETDB1 in the Disease Pathogenesis

组蛋白甲基转移酶家族是表观遗传调控的关键参与者。SET结构域分支型1(SETDB1)是组蛋白甲基转移酶家族的成员,其在组蛋白H3上甲基化赖氨酸9位点,在涉及转录抑制和常染色体基因沉默的生物网络中显示多重功能。该综述总结了SETDB1的结构和功能,以及相关疾病的发生和发展所涉及的分子机制的最新进展,以期对疾病诊断和临床治疗有所帮助。

The histone methyltransferase family is the crucial participant in epigenetic regulation.SET domain bifurcated 1(SETDB1),a member of the histone methyltransferase family,methylates lysine 9 position on histone H3 and shows multiply function in biological networks involving in transcriptional inhibition and autosomal gene silencing.This review summarizes the structure and function of SETDB1,the latest advances in the molecular mechanisms involved in the development and progression of related diseases,which highlight novel strategies for theoretical guidance and clinical treatment.