Sirtuins与自噬在卵母细胞老化中的作用

The Roles of Sirtuins and Autophagy in Oocyte Aging

长时间未受精的卵母细胞不可避免地发生细胞核与细胞质的老化,并伴有受精率的降低、胚胎发育缺陷等问题。Sirtuins是烟酰胺腺嘌呤二核苷酸(nicotinamide adenine dinucleotide,NAD+)依赖组蛋白去乙酰酶,通过调控代谢对细胞的老化有延缓和抑制的作用。该文综述了老化的卵母细胞中细胞核、细胞质、细胞器和乙酰化的改变。阐述了sirtuins的功能、sirtuins与卵母细胞老化之间的关系及与自噬之间的关系。讨论了通过调控sirtuins延缓和改善卵母细胞老化的可行性。

Long-term unfertilized oocytes inevitably undergo nuclear and cytoplasmic aging,which will lead to fertilization and development defects.Sirtuins is a NAD+-dependent histone deacetylase,through regulating the metabolism of cells aging delaying and inhibiting effects.In this review,we summarized the changes of aging oocytes in nucleus and cytoplasm.In addition,the functions of sirtuins,the relationship between sirtuins and postovulatory aging,and relationship between sirtuins and autophagy.It is also discussed that the regulation of sirtuins may delay and improve the aging of oocytes.