转录中介体复合物与转录及表观遗传调控

Mediator in Transcriptional and Epigenetic Regulation

在真核生物中基因的转录受到严格而精确的调控,转录中介体复合物(Mediator Complex)能够直接与转录机器相互作用,调控转录的起始、延伸及终止等过程。此外,组蛋白修饰、染色质三维结构的改变对转录的调控也至关重要,转录调控的紊乱往往会导致发育异常以及疾病的发生。该文主要论述Mediator复合物在转录与表观遗传学调控(包括染色质高级结构动态变化)中的分子机制及功能作用。

The transcription of genes is controlled strictly and precisely in eukaryotes.The Mediator complex orchestrates multiple transcription factors with transcriptional machinery to regulate the initiation,elongation and termination of transcription.In addition,epigenetic regulations including histone modifications,higher order chromatin structure are also crucial for the transcriptional regulation.And dysfunctions of transcriptional regulation often lead to developmental abnormalities and diseases.This paper mainly focuses on the molecular mechanisms and functional roles of the Mediator Complex in transcriptional and epigenetic regulation,including dynamic changes in chromatin structure.