体细胞重编程机制研究进展

Research Progress on Somatic Cell Reprogramming Mechanism

体细胞重编程是生命科学以及再生医学领域的研究热点之一,目前包括体细胞核移植、细胞融合和转录因子诱导等几种方法都可以实现体外重编程。数量众多的表观遗传修饰在重编程过程中发挥着关键作用,因此,了解表观遗传修饰的动态变化以及各自的作用有助于更好地理解、优化以及运用重编程技术。该文简要阐述了体细胞核移植技术和诱导多能干细胞技术的发展历程和研究进展,并讨论这两种重编程过程中的表观遗传调控机制。

Somatic cell reprogramming is one of the research focuses in life sciences and regenerative medicine fields.At present,several methods such as somatic cell nuclear transfer,cell fusion and transcription factor induction can achieve in vitro reprogramming.A large number of epigenetic modifications play a key role in the reprogramming process.Therefore,understanding the dynamic changes of epigenetic modifications and their respective roles helps to better comprehend and apply reprogramming techniques.This article briefly reviews the development history and research progress of somatic cell nuclear transfer technology and induced pluripotent stem cell technology,and discusses the epigenetic mechanisms existing in these two reprogramming processes.