压应力对软骨细胞的影响

Effects of Compression on Chondrocytes

骨关节炎(osteoarthritis, OA)是一种以关节软骨退变、软骨下骨重塑、骨赘形成、关节内滑膜炎症反应和广泛血管生成为特征的慢性退行性疾病。其发生受遗传、环境、代谢、生物化学和机械应力等诸多因素的共同影响,其中机械应力异常为主要诱因。在机械应力异常导致OA的过程中,软骨组织的稳定状态被打破,软骨细胞作为软骨组织中唯一的细胞也会发生相应的变化。压应力是机械应力的一种,最新研究表明,压应力可对软骨细胞的形态、代谢状态、表型、细胞活性产生影响。因此,该文综述了近年来压应力对软骨细胞影响的相关文献,为OA的机制和治疗有关研究提供理论基础。

Osteoarthritis(OA)is a chronic degenerative disease characterized by articular cartilage degeneration,subchondral bone remodeling,osteophyte formation,intra-articular synovial inflammation,and extensive angiogenesis.Its occurrence is affected by many factors such as genetics,environment,metabolism,biochemistry and mechanical stress,among which mechanical stress anomalies are the main cause.In the process of OA caused by abnormal mechanical stress,chondrocytes will change.Compressive stress is a kind of mechanical stress.Recent studies have shown that compressive stress can affect the morphology,metabolic state,phenotype and cell viability of chondrocytes,which in turn affects the development of OA.Therefore,this paper reviews the literature on chondrocytes under compression in recent years to provide theoretical basis for the study of OA mechanism and treatment.