姜黄素在动物脂肪生成过程中的调控作用

Regulation of Adipogenesis in Animals by Curcumin

脂肪细胞的增殖、分化即脂肪细胞数目的增加和体积的增大导致了机体脂肪组织的沉积,而肥胖程度的高低是由脂肪细胞数量的多少及体积的大小决定的。脂肪细胞凋亡的直接结果是脂肪细胞的数目减少、机体的脂肪含量降低。姜黄素是一种提取于姜黄根茎、具有较强生物学活性的天然黄色多酚类化合物,其可对脂肪细胞的发育过程进行调控,诱导白色脂肪细胞转化为棕色脂肪细胞,并可改善脂肪细胞的内质网应激、脂质代谢失调、肥胖引起的糖代谢失调和肥胖相关炎症。该文对姜黄素在动物脂肪细胞增殖、分化、凋亡、脂代谢、白色脂肪细胞棕色化中的作用以及在此过程中涉及的信号通路进行总结,对其在肥胖及并发症的预防及治疗方面的应用进行探讨,以期为研究姜黄素调控动物脂肪生成及肥胖相关疾病的科研人员提供参考。

The proliferation and differentiation of adipocytes,which increase the number of the cells and the the size of a single cell,lead to the deposition of adipose tissue in living animals,and the degree of obesity is determined by the fat cells’number and size.The direct result of adipocyte apoptosis is a decrease in the number of fat cells,which in turn reduces the amount of adipose tissue in vivo.Curcumin is a kind of natural yellow polyphenols extracted from turmeric rhizome,and it has strong biological activity.Curcumin can regulate the development process of adipocytes,turn white adipocytes into beige cells,and improve endoplasmic reticulum stress,lipid metabolism disorder,glucose metabolism disorder caused by obesity and obesity-related inflammation in body.The recent progress about the effects of curcumin on the proliferation,differentiation,apoptosis,lipid metabolism of adipocytes and the signaling pathways involved in these processes were summarized,and the effects of curcumin on the prevention and treatment of obesity and its complications were discussed in this review.It may provide a useful reference for researchers’working in this field.