新辅助化疗在宫颈癌治疗中的应用及疗效观察

Application and curative effect of neoadjuvant chemotherapy in the treatment of cervical cancer

目的:探讨新辅助化疗(NACT)在宫颈癌治疗中的应用效果。方法:收治Ⅰb2～Ⅱa宫颈癌患者82例,其中行NACT+子宫切除术42例(NACT组),仅子宫切除术40例(对照组)。观察行NACT前后癌灶变化及两组子宫切除率、术中出血量及手术时间。结果:23例Ⅰb2期患者行NACT治疗的有效率82.61%,Ⅱa期患者行NACT治疗的有效率73.68%。NACT组在子宫切除率、术中平均出血量及手术平均时间均优于对照组,两组比较差异有统计学意义(P<0.01)。结论:宫颈癌患者应用NACT技术能够有效减小肿瘤体积,缩小肿瘤范围,便于进一步的手术治疗,并提升了手术质量。

Objective:To explore the application of neoadjuvant chemotherapy(NACT)effect in the treatment of cervical cancer.Methods:Select the Ⅰb2-Ⅱa 82 cases of cervical cancer patients in our hospital,including NACT+hysterectomy in 42 cases(NACT group),40 cases of hysterectomy(control group).Observe the changes of uterine resection rate,the amount of bleeding and operation time before and after NACT carcinomas.Results:In 23 stage I b2 patients underwent NACT treatment efficiency was 82.61%,in stage a NACT patients treated with effective rate of 73.68%.In group NACT,the rate of hysterectomy,average intraoperative bleeding volume and the average time of operation was better than the control group,there was significant difference between two groups(P<0.01).Conclusion:Application of NACT technology in patients with cervical cancer can be effectively reduced tumor volume,the tumor range,be helpful for further surgery,and improve the operation quality.