慢性阻塞性肺病合并心力衰竭时血浆B型尿钠肽变化分析

To analysis the changes of plasma B-type natriuretic peptide in chronic obstructive pulmonary disease with heart failure

目的:探讨慢性阻塞性肺病合并心力衰竭时血浆B型尿钠肽的水平及临床意义。方法:选择慢性阻塞性肺病患者120例,所有入选者按照美国纽约心脏病协会(NYHA)分级方案将心功能分为Ⅰ~Ⅳ级,同时经2名高年资主治医师确认。采用免疫荧光法测定B型尿钠肽水平,并进行比较。结果:重度心力衰竭组B型尿钠肽水平显著高于轻中度心力衰竭组,心力衰竭与B型尿钠肽水平有较强的正相关性。结论:慢性阻塞性肺病合并心力衰竭时血浆B型尿钠肽水平增高,B型尿钠肽增高的程度与心力衰竭有较强的正相关。

Objective:To explore the changes and clinical significance of plasma B type natriuretic peptide in chronic obstructive pulmonary disease associated with heart failure.Methods:We selected 120 cases of patients with chronic obstructive pulmonary disease.All the patients heart function was divided into Ⅰ~Ⅳ grade according to USA New York Heart Association(NYHA)classification scheme and confirmed by 2 senior doctors at the same time.We used immunofluorescence method for the determination of B type natriuretic peptide levels and compared them.Results:The B type natriuretic peptide levels of severe heart failure group were significantly higher than the mild to moderate heart failure group and there was a positive correlation between the heart failure and B type natriuretic peptide levels.Conclusion:Plasma B type natriuretic peptide levels were increased in the chronic obstructive pulmonary disease associated with heart failure.There was a positive correlation between the heart failure and B type natriuretic peptide levels.