摘要
目的:通过检测妇产科呼吸困难患者血清N末端B型钠尿肽原(NT-proBNP)水平,探讨NT-proBNP在心源性和非心源性呼吸困难的临床鉴别价值。方法:对妇产科病房急性呼吸困难患者69例临床干预前抽取静脉血,采用电化学发光免疫分析(ECLIA)法检测血清NT-proBNP。结果:心源性呼吸困难组血清NT-proBNP水平显著高于非心源性呼吸困难组(P<0.01),其阳性率也显著高于后者(P<0.01)。据血清NT-proBNP>100pg/ml为标准诊断心源性呼吸困难时,敏感度、特异度、阳性预测值及阴性预测值分别为100%、92.9%、95.4%和100%;据血清NT-proBNP>130pg/ml为标准诊断心源性呼吸困难时,敏感度、特异度、阳性预测值及阴性预测值均100%。结论:妇产科心源性呼吸困难患者血清NT-proBNP水平显著高于非心源性呼吸困难患者,血清NT-proBNP可作为鉴别心源性与非心源性呼吸困难的一项观察指标,具有敏感性和特异性高的特点。
Objective:To explore the clinical diagnostic value of NT-proBNP in cardiac and non cardiac dyspnea through the detection serum N terminal B type natriuretic peptide(NT-proBNP) level of Obstetrics and Gynecology patients with difficulty breathing.Methods:69 patients with acute dyspnea in maternity wards extracted venous blood before clinical intervention,to detect serum NT-proBNP by ECLIA method.Results:Cardiac dyspnea group had a significantly higher serum level of NT-proBNP in patients with non cardiac patients with dyspnea group(P<0.01),the positive rate was also significantly higher than the latter(P<0.01).According to the serum NT-proBNP>100pg/ml of standard in the diagnosis of cardiac dyspnea,sensitivity and positive predictive value and negative predictive value and specific degrees were respectively 100% and 92.9% and 95.4% and 100%.According to the serum NT-proBNP>130pg/ml for the standard in the diagnosis of cardiac dyspnea,sensitivity and specific degrees and positive predictive value and negative predictive value of 100%.Conclusions:Obstetrics and gynecology patients with cardiac dyspnea is significantly higher than the level of serum NT-proBNP in patients with cardiac dyspnea.NT-proBNP serum can beused as identification of cardiac and non cardiac dyspnea an observational indexes,with characteristics of high sensitivity and specificity.
