颅脑损伤并发抗利尿激素分泌失调综合征17例临床分析

Clinical analysis of 17 cases of syndrome of inappropriate antidiuretic hormone with brain injury

目的:探讨颅脑损伤并发抗利尿激素分泌失调综合征临床特点和治疗效果。方法:收治颅脑损伤患者17例,入院时电解质等正常,入院后7~14天,有不同程度的低钠血症、低氯血症、低血浆渗透压、高尿钠症,诊断为抗利尿激素分泌失调综合征。结果:给予对症处理后,患者血钠水平和尿钠水平恢复到正常范围,病情均好转,无1例死亡。结论:颅脑损伤并发抗利尿激素分泌失调综合征的早发现早治疗,有利于改善患者预后,降低患者病死率和致残率。

Objective:To investigate clinical characteristics and the therapeutic effect of the brain injury with syndrome of inappropriate antidiuretic hormone.Methods:From 2009 to 2013,17 patients with craniocerebral injury treated,admission electrolyte were normal,7~14days after admission,had different degree of hyponatremia,hypochloremia,plasma osmotic pressure, high urine sodium disease,diagnosis of syndrome of inappropriate antidiuretic hormone.Results:After the treatment,the patients serum sodium levels and urinary sodium levels returned to the normal range,the condition was improved,and no death.Conclusion: Early detection and early treatment of syndrome of inappropriate antidiuretic hormone with brain injury improve the prognosis of patients,reduce the mortality and disability rate.