超常规剂量奥曲肽对食管胃底静脉曲张破裂大出血治疗效果及输血量影响的临床研究

The clinical study of treatment effect and effect of blood transfusion amount of ultra conventional doses of octreotide in the treatment of esophageal and gastric variceal bleeding

目的:观察超常规剂量奥曲肽对食管胃底静脉曲张破裂大出血治疗效果及输血量影响。方法:将222例患者随机分为治疗组(112例)和对照组(110例),分别给予奥曲肽,以每小时50μg和25μg的速度静脉微量泵持续泵入。结果:治疗组显效率62.5%,有效率32.1%,总有效率94.6%。总输血量392U悬浮红细胞,平均(3.1±0.4)U;对照组显效率46.3%,有效率32.7%,总有效率79.0%。总输血量598U悬浮红细胞,平均(5.0±0.5)U;经χ2检验和t检验差异有统计学意义(P<0.05)。结论:超常规剂量(50μg/小时)奥曲肽治疗肝硬化食管静脉曲张破裂出血,起效快,效果佳,显著减少输血量,可作为本症的常规治疗剂量以有效快速止血。

Objective:To explore the treatment effect and effect of blood transfusion amount of ultra conventional doses of octreotide in the treatment of esophageal and gastric variceal bleeding.Methods:222 patients were randomly divided into treatment group(112 cases) and control group(110 cases),were given respectively octreotide each hour 50 ?g and 25 ?g by intravenous infusion pump.Results:In the treatment group,the significant effective rate was 62.5%,effective rate was 32.1%,the total efficiency was 94.6%,total output was 392U suspended red blood cells,the average was(3.1±0.4)U.In the control group,the significant effective rate was 46.3%,effective rate was 32.7%,the total efficiency was 79%.The total output was 598U suspended red blood cells,the average was(5±0.5)U.There were statistically significant differences by χ2test and t test(P<0.05).Conclusion:Ultra conventional doses of octreotide(50μg/hour) in the treatment of esophageal and gastric variceal bleeding can significantly reduce the volume of blood transfusion,and the onset was quick,the effect was good.It can be used as the dose in the conventional treatment with effective hemostasis.