质子泵抑制剂对根除幽门螺旋杆菌的影响

Impact of proton pump inhibitors on Helicobacter pylori eradication

目的:探讨根除幽门螺旋杆菌(Hp)治疗前是否需停用质子泵抑制剂(PPI)。方法:随机将86例需要根除Hp的患者(治疗前已使用了质子泵抑制剂)分为治疗组和对照组,治疗组直接加用根除Hp的标准三联药物(奥美拉唑20mg/次,2次/日+克拉霉素500mg/次,2次/日+阿莫西林1000mg/次,2次/日),对照组停用质子泵抑制剂2周后再加用根除Hp的标准三联药物,疗程均7天,治疗结束后使用14C-尿素呼气试验评估Hp根治疗效。结果:治疗组和对照组Hp根除率分别为80.95%、84.09%,两组间比较差异无统计学意义(P>0.05)。结论:根除Hp治疗前无需停用质子泵抑制剂。

Objective:To investigate if it is necessary to stop using PPI before the therapy of Hp eradication.Methods:A total of 84 Hp-infected patients were randomly assigned into therapeutic group and control group,the first group were treated directly with omeprazde 20mg bid+clarithromycin 500mg bid+amoxicillin 1000mg bid for 7 days,the second group were given equal scheme but stop using PPI for two weeks before therapy,After treatment,14C-urea breath test were performed to assess Hp eradication. Results:Hp eradication rates were 80.95% in therapeutic group and 84.09% in control group respectively,there were no significant differences between the two groups(P>0.05).Conclusions:It is not necessary to stop using PPI before the therapy of Hp eradication.