摘要
目的:了解南京地区育龄妇女孕前TORCH感染的发生率及其自然免疫状况。方法:采用酶联免疫法检测进行孕前检查的育龄妇女孕前血清TORCH特异性IgM和IgG抗体水平。结果:①TOX-IgM,CMV-IgM,RV-IgM及HSV-Ⅱ-IgM的阳性率分别为0.28%(65/23481),1.46%(329/22596),0.42%(94/22515)和3.47%(794/22913);TOX-IgG,CMV-IgG,RV-IgG及HSV-Ⅱ-IgG的阳性率分别为3.53%(830/23481),97.3%(21912/22596),84.1%(18923/22515)和6.44%(1476/22913)。②南京地区育龄妇女CMV-IgM,HSV-Ⅱ-IgM阳性率季节差异有统计学意义(CMV-IgM:χ2=14.193,P=0.003;HSV-Ⅱ-IgM:χ2=15.521,P=0.001)。TOX-IgM和RV-IgM阳性率差异则无统计学意义。结论:孕前TORCH抗体筛查对于临床开展优生优育具有非常重要的指导意义,育龄妇女应警惕TORCH感染的季节性,降低感染率,减少残障儿出生的可能性。
Objective:To investigate the incidence and its natural immune status of pregnant TORCH women of childbearing age infection in Nanjing area.Methods:Using enzyme-linked immunosorbent assay to detect the Pre pregnancy serum TORCH specific IgM and IgG antibody levels in women of chi1dbearing age.Results:①The positive rates of TOX-IgM,CMV-IgM,RV-IgM,and HSV-Ⅱ-IgM were 0.28%(65/23481),1.46%(329/22596),0.42%(94/22515)and 3.47%(794/22913) respectively.The positive rates of TOX-IgG,CMV-IgG,RV-IgG,and HSV-Ⅱ-IgG were 3.53%(830/23481),97.3%(21912/22596),84.1%(18923/22515) and6.44%(1476/22913)respectively.②The calendar variation of the positive rates of CMV-IgM and HSV-Ⅱ-IgM in women of chi1dbearing age in Nanjing area had statistical significance(CMV-IgM:X2=14.193,P=0.003;HSV-Ⅱ-IgM:X2=15.521,P=0.001).The difference of the positive rates of TOX-IgM and RV-IgM had no statistical significance.Conclusion:Pre pregnancy TORCH antibody screening has a very important significance in developing eugenics in clinical.Women of childbearing age should be alert to the seasonal TORCH infection,reduce the rate of infection,reduce the possibility of handicapped children born.
基金
江苏省卫生厅科技项目(H201343)
关键词
TORCH感染
孕前育龄妇女
季节
TORCH infection
Pre pregnancy women of childbearing age
Seasonal