糖化血红蛋白在诊断糖尿病与前驱糖尿病患者中的作用

Use of Glycated Hemoglobin in the Diagnosis of Diabetes Mellitus and Pre-diabetes

目的:探讨相对于空腹血糖(FPG)和OGTT,糖化血红蛋白(HbA1c)在诊断糖尿病及前驱糖尿病的效力。方法:选取89例可疑糖尿病患者纳入研究,根据美国糖尿病协会新的诊断标准将患者分为糖尿病患者、前驱糖尿病患者、非糖尿病患者,分析FPG、OGTT和HbA1c数据。结果:以HbA1c为标准,69.7%患者诊断为糖尿病;以2小时OGTT为标准,64.3%患者诊断为糖尿病;以FPG为标准,43.1%患者诊断为糖尿病。FPG与2小时OGTT,FPG与HbA1c,OGTT与HbA1c之间差异均有统计学意义(P<0.05)。结论:作为一种新的筛选方法,HbA1c在鉴别糖尿病与前驱糖尿病患者中更胜一筹。

Objectives:The study goal was to clarify the power and efficacy of glycated hemoglobin(HbA1c)in the diagnosis of diabetes and pre-diabetes by comparing against the other American Diabetes Association(ADA)diagnostic criteria of fasting plasma glucose(FPG)and oral glucose tolerance test(OGTT).Methods:A total of 89 individuals attended to the internal medicine outpatient clinic in 2013 years were screened.The results of FPG,OGTT and HbA1c for 89 individual were analyzed and all grouped as diabetic patients,glucose intolerant(pre-diabetes)patients and non-diabetic patients according to new ADA criteria for the diagnosis of diabetes.Results:The prevalence of newly diagnosed diabetes was 69.7% by using HbA1calone,64.3% with 2h OGTT alone and 43.1%,respectively with FPG alone.Differences between FPG versus 2h OGTT,FPG versus HbA1cand OGTT versus HbA1cwere statistically significant(P<0.05,respectively).Conclusions:As a screening tool for newly diagnosed diabetes and pre-diabetes,the HbA1clevel performed better than FPG and 2h OGTT in this general population.