摘要
目的:探讨小剂量和大剂量胰岛素治疗小儿糖尿病酮症酸中毒的疗效差异。方法:收集60例小儿糖尿病酮症酸中毒患儿,随机分成小剂量组和大剂量组,小剂量组给予胰岛素剂量0.05~0.1U/(kg·小时)治疗;大剂量组给予胰岛素剂量0.11~0.20U/(kg·小时)治疗。结果:两组患儿空腹血糖、餐后2小时血糖、尿酮体转阴时间比较差异无统计学意义(P>0.05),但是大剂量组血糖下降速度明显高于小剂量组,两组比较差异有统计学意义(P<0.05)。结论:小剂量和大剂量胰岛素治疗小儿糖尿病酮症酸中毒的疗效差异不大,但使用剂量较小血糖下降的速度比较适中,可有效避免发生低血糖。
Objective:To explore the curative effect difference of small dose and large dose of insulin in the treatment of children with diabetic ketoacidosis.Methods:To collect 60 cases of children with diabetic ketoacidosis,were randomly divided into small dose group and large dose group,the small dose group were given insulin dose of 0.05~0.1U/(kg·h)treatment;the large dose group were given insulin dose of 0.11~0.20U/(kg·h)treatment.Results:The fasting blood glucose,postprandial 2 hour blood glucose, ketonuria time of the two groups of children were no significant difference(P>0.05),but blood glucose decreased of the large dose group was significantly higher than that in small dose group,there were significant difference between two groups(P<0.05). Conclusion:The differences of therapeutic efficacy between small and large doses of insulin in the treatment of children with diabetic ketoacidosis is litter,but the use of small dose of glucose decreased speed is moderate,can effectively avoid the occurrence of hypoglycemia.
