快速性心律失常患儿血清N末端脑型钠尿肽的变化

Changes of N terminal pro brain natriuretic peptide in serum of children with tachyarrhythmia

目的:探讨快速性心律失常患儿转律前后血清N末端脑型钠尿肽(NT-proBNP)的变化,并评价其对心律失常的临床诊断、预后评估作用。方法:收治快速性心律失常患儿60例,快速性心律失常转律前后测定血清NT-proBNP水平及左心室射血分数(EF)、左室舒张末期直径(LVDD),健康儿童60例作为对照组,测定血清NT-proBNP水平及EF、LVDD。结果:快速性心律失常转律前的NT-proBNP水平明显高于快速性心律失常转律后1周的NT-proBNP水平和对照组NT-proBNP水平,差异均有统计学意义。快速性心律失常转律后1周的NT-proBNP水平与健康对照组比较无统计学意义;快速性心律失常转律前的EF、LVDD与快速性心律失常转律后1周以及健康对照组比较无统计学意义。结论:血清NT-proBNP的定量检测可为快速性心律失常的诊断及预后评估提供直接病理生理学依据。

Objective:To investigate the changes of N terminal pro brain natriuretic peptide(NT-proBNP)in serum before and after cardioversion in children with tachyarrhythmia.We evaluated its clinical diagnosis,prognosis evaluation for arrhythmias.Methods:60 patients with tachyarrhythmia in children were selected.We determined the level of NT-proBNP in serum,left ventricular ejection fraction(EF) and left ventricular end diastolic diameter(LVDD) before and after the cardioversion of tachyarrhythmia.60 healthy children were selected as the control group,they were also determined the serum NT-proBNP level and EF,LVDD.Results:The level of NT-proBNP before the tachyarrhythmia cardioversion were significantly higher than that after the tachyarrhythmia cardioversion and the control group,there were statistically significant.There were no statistical significance between the NT-proBNP level of after tachyarrhythmia cardioversion 1 weeks and that of the healthy control group.There were no statistical significance among the EF,LVDD of before the tachyarrhythmia cardioversion and after cardioversion for a week and the healthy control group.Conclusion:It can provide direct pathophysiological basis for diagnosis and prognostic evaluation of tachyarrhythmia by the quantitative detection of serum NT-proBNP.