甘精胰岛素联合瑞格列奈治疗初诊2型糖尿病的疗效观察

Curative effect observation of insulin glargine combined with repaglinide in the treatment of newly diagnosed type 2 diabetes

目的:探讨甘精胰岛素联合瑞格列奈治疗初诊2型糖尿病的临床疗效。方法:收治初诊T2DM患者40例,经甘精胰岛素联合瑞格列奈治疗16周,比较治疗前后空腹血糖(FBG)、餐后2小时血糖(PBG)、糖化血红蛋白(HbA1C)的差异,同时观察总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、血常规、肝、肾功能的变化及体重指数(BMI),低血糖的药物不良反应。结果:治疗12周后,与治疗前相比,FBG、PBG、HbA1C均降低(P<0.05),TC、TG、LDL-C,血常规、肝、肾功能、BMI与治疗前相比差异无统计学意义(P>0.05),有低血糖反应3例次。结论:甘精胰岛素联合瑞格列奈治疗初诊T2DM患者,能使血糖下降明显,且不良反应轻微、安全。

Objective:To investigate the clinical efficacy of insulin glargine combined with repaglinide in the treatment of newly diagnosed type 2 diabetes.Methods:40 newly diagnosed patients with T2DM were selected,they were treated with insulin glargine combined with repaglinide for 16 weeks.Fasting blood glucose(FBG),2 hour postprandial blood glucose(PBG),glycosylated hemoglobin(HbA1C) before and after treatment were compared.At the same time,total cholesterol(TC),triglyceride(TG),low density lipoprotein(LDL-C),blood routine,liver and kidney function and body mass index(BMI),hypoglycemia were observed.Results:After12 weeks of treatment,compared with before treatment,FBG,PBG,HbA1C were decreased(P<0.05);TC,TG,LDL-C,blood routine,liver and renal function,BMI compared with before treatment had no significant difference(P<0.05);hypoglycemia occurred in 3cases.Conclusion:Insulin glargine combined with repaglinide in the treatment of newly diagnosed T2DM patients can make blood sugar decreased obviously,it has minor side effects,and it is safety.