摘要
目的:对隐性梅毒患者进行免疫增强治疗,并观察其对患者Th1/Th2细胞因子的影响。方法:收治隐性梅毒患者40例,通过对比分析法对其临床资料进行分析,并应用免疫增强疗法进行治疗。用随机抽取法将患者分为对照组与治疗组,对照组采用苄星青霉素常规治疗法进行治疗,治疗组应用苄星青霉素常规治疗法联合金菌灵胶囊进行治疗,每组20例,并选取20例普通患者作为正常组进行对比性分析,应用酶联免疫吸附试验对这3组血清中的IFN-γ、IL-2、IL-10、IL-4的水平进行检测并分析。结果:相较于对照组正常人而言,隐性梅毒患者血清中的IFN-γ、IL-2的水平明显要低,而IL-10、IL-4的水平明显要高,其数据对比差异有统计学意义,P<0.01。治疗组治疗3个月以及6个月后其血清中IFN-γ、IL-2水平呈现升高趋势,而IL-10、IL-4的水平呈现下降趋势。结论:隐性梅毒患者在接受免疫增强治疗过程中有利于调节其紊乱的免疫调节功能,改变Th2型细胞因子占据主导地位的局势,从而增强患者机体免疫力,提高治疗效果。
Objective:To observe the effect of Th1/Th2 cytokines of patients with latent syphilis that were treated with immune enhancement therapy.Methods:40 patients with latent syphilis were selected.Their data were clinical analyzed through comparative analysis,and all patients were treated with immune enhancement therapy.They were divided into the control group and the treatment group.The control group was treated with benzyl penicillin of conventional therapy.The treatment group was treated with benzyl penicillin of conventional therapy combined with golden carbendazim capsule.There were 20 cases in each group.20 normal patients were selected as the normal group for comparative analysis.The levels of serum 1FN-γ,1L-2,1L-10,1L-4 of these 3 groups were detected and analyzed by enzyme-linked immunosorbent assay.Results:Compared with the normal people of the control group,the levels of serum 1FN-γ,1L-2 of the patients with latent syphilis were significantly lower,the levels of serum 1L-10,1L-4 were significantly higher.The differences was statistically significant(P<0.01).The patients in the treatment group were treated for 3 months and 6 months,the levels of serum 1FN-γ,1L-2 were increased,while the levels of serum 1L-10,1L-4 were decreased.Conclusion:The immune enhancement therapy in the treatment of patients with latent syphilis is conducive to the regulation of immune regulation function,can change the Th2 type cytokines in the dominant situation,thereby enhance the body immunity,improve the clinical therapeutic effect.
